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The aprotinin saga and the risks of conducting meta-analyses on small randomised controlled trials – a critique of a Cochrane review
18
Zitationen
1
Autoren
2009
Jahr
Abstract
It is doubtful whether small studies should be included in meta-analyses if they do not have the purpose of studying the specified outcome and if the follow-up method or time are not adequately described. The aprotinin saga shows overconfidence in small RCTs of inferior quality compared to well-conducted observational studies.
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