Dies ist eine Übersichtsseite mit Metadaten zu dieser wissenschaftlichen Arbeit. Der vollständige Artikel ist beim Verlag verfügbar.
Application of Palladium-Mediated 18F-Fluorination to PET Radiotracer Development: Overcoming Hurdles to Translation
98
Zitationen
8
Autoren
2013
Jahr
Abstract
New chemistry methods for the synthesis of radiolabeled small molecules have the potential to impact clinical positron emission tomography (PET) imaging, if they can be successfully translated. However, progression of modern reactions from the stage of synthetic chemistry development to the preparation of radiotracer doses ready for use in human PET imaging is challenging and rare. Here we describe the process of and the successful translation of a modern palladium-mediated fluorination reaction to non-human primate (NHP) baboon PET imaging-an important milestone on the path to human PET imaging. The method, which transforms [(18)F]fluoride into an electrophilic fluorination reagent, provides access to aryl-(18)F bonds that would be challenging to synthesize via conventional radiochemistry methods.
Ähnliche Arbeiten
Fluorine in medicinal chemistry
2007 · 7.309 Zit.
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 · 6.420 Zit.
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 · 4.655 Zit.
Understanding organofluorine chemistry. An introduction to the C–F bond
2007 · 3.815 Zit.
The Many Roles for Fluorine in Medicinal Chemistry
2008 · 3.509 Zit.