Dies ist eine Übersichtsseite mit Metadaten zu dieser wissenschaftlichen Arbeit. Der vollständige Artikel ist beim Verlag verfügbar.
Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
4.257
Zitationen
12
Autoren
2003
Jahr
Abstract
Various chronic antidepressant treatments increase adult hippocampal neurogenesis, but the functional importance of this phenomenon remains unclear. Here, using genetic and radiological methods, we show that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants. Serotonin 1A receptor null mice were insensitive to the neurogenic and behavioral effects of fluoxetine, a serotonin selective reuptake inhibitor. X-irradiation of a restricted region of mouse brain containing the hippocampus prevented the neurogenic and behavioral effects of two classes of antidepressants. These findings suggest that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neurogenesis in the hippocampus.
Ähnliche Arbeiten
Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
2016 · 8.955 Zit.
Neurogenesis in the adult human hippocampus
1998 · 6.279 Zit.
Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System
1992 · 5.375 Zit.
Cerebral organoids model human brain development and microcephaly
2013 · 5.250 Zit.
Astrocytes: biology and pathology
2009 · 5.055 Zit.