Autologous Blood Transfusions (A Study of 210 Cases).

Abstract

Autologous blood is generally considered the safest blood transfusion method. Perioperative homologous blood transfusion is associated with numerous problems such as transmission of certain diseases, such as GVHD (graft-versus-host disease), or AIDS (transfus ion-transmitted acquried immune deficiency syndrome). To defermine whether the administration of recombinant human erythropoietin (rh-EPO) increases the amount of autologous blood that can be collected prior to surgery, we studied 210 adults scheduled for elective orthopedic procedures. 183 of these patients were administered rh-EPO [group EPO (+)], and 27 patients were not [group EPO (-)]. All patients received iron sulfate. The mean autologous blood volume collected was significantly greater in the group EPO (+) than in the group EPO (-) (890vs. 677ml; p<0.0001). The preoperative group EPO (+) showed a greater increase in the mean haemoglobin concentration than the group EPO (-). (2.095vs. 0.915g/dl; p<0.0001). Postoperative haemoglobin recovered significantly more rapidly in the group EPO (+). We conclude that recombinant human erythropoietin increases the ability of patients about to undergo elective surgery to donate autologous blood.

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