Bone metabolism and trauma degree of magnetic-guided intramedullary nail fixation for femoral shaft fracture

Abstract

Objective: To explore the effect of magnetic-guided intramedullary nail fixation on bone
\nmetabolism and trauma degree in patients with femoral shaft fracture. Methods: A total of 128
\npatients with femoral shaft fractures who received surgical treatment in the hospital between
\nApril 2016 and November 2017 were divided into control group (n=64) and study group
\n(n=64) according to the random number table method. Control group received the traditional
\nintramedullary nail treatment, and study group received magnetic-guided intramedullary nail
\ntreatment. The differences in serum levels of bone metabolism indexes and inflammatory
\nfactors were compared between the two groups 48 h after surgery. Results: 48 h after surgery,
\nserum bone formation indexes BGP, PⅠNP, PⅠCP and BAP levels of study group were
\nhigher than those of control group whereas bone resorption indexes β-CTX, TRACP5b and
\nNTX levels were lower than those of control group; serum inflammatory factors TGF-β,
\nhs-CRP, IL-1β, IL-6 and IL-17 levels were lower than those of control group. Conclusion:
\nCompared with traditional intramedullary nail therapy, magnetic-guided intramedullary nail
\nfixation can more effectively balance the bone metabolism status and reduce the fracture end
\ntrauma in patients with femoral shaft fracture.

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