Journal-related Activities and Other Special Activities at the 2022 American Society of Anesthesiologists Meeting

Abstract

As in previous years, Anesthesiology will sponsor several sessions at the annual meeting of the American Society of Anesthesiologists (ASA; Schaumburg, Illinois), Anesthesiology 2022. The meeting is being held in New Orleans, Louisiana. Details about the format and meeting attendance can be found on the website, asahq.org/annualmeeting.Saturday October 22, 2022, 1:15pmto 3:15pmRoom 243Sachin Kheterpal, M.D., M.B.A., Editor, Anesthesiology, University of Michigan, Ann Arbor, Michigan.“Progress and Missteps in Perioperative Medicine Big Data Research” by Sachin Kheterpal, M.D., M.B.A., University of Michigan, Ann Arbor, Michigan.“Choosing Wisely in Big Data Analysis: Risk Adjustment, Prediction, or Causation” by Elizabeth L. Whitlock, M.D., M.A., M.Sc., University of California, San Francisco, California.“High-Stakes Epidemiology: Using Big Data to Estimate Causal Effects” by Brian T. Bateman, M.D., Stanford University School of Medicine, Stanford, California.“Exciting Developments in Big Data Analysis Methods” by Timothy T. Houle, Ph.D., Massachusetts General Hospital, Boston, Massachusetts.Research, quality improvement, clinical guideline, and policy-making efforts based upon “big data” are increasingly common in perioperative medicine. All anesthesiologists must be facile in understanding and communicating the strengths and weaknesses of these databases and projects. This session will arm every anesthesiologist with the skills necessary to consume or create the in vogue and ubiquitous “big data” study with a discerning eye.Saturday, October 22, 2022, 3:30pmto 4:30pmRoom 243Evan D. Kharasch, M.D., Ph.D., Editor-in-Chief, Anesthesiology, Duke University Medical Center, Durham, North Carolina; Deborah J. Culley, M.D., Executive Editor, Anesthesiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.Anesthesiology is sponsoring its seventh Major Clinical Trials Session, a high-profile, large-audience forum for initial presentations of major randomized clinical trial results. It is designed for substantial trials, usually randomized and blinded, with a clinically important primary outcome.Sunday, October 23, 2022, 8:30amto 11:30amRoom 243Deborah J. Culley, M.D., Executive Editor, Anesthesiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania; Andrew Davidson, M.B.B.S., M.D., Executive Editor, Anesthesiology, Royal Children’s Hospital, Melbourne, Australia.Postoperative delirium affects a substantial portion of surgical patients and is associated with both short- and long-term complications and morbidity. The science behind delirium is rapidly evolving with better diagnostic tools, a greater understanding of the neurobiology, and greater understanding of the possible etiology. The symposium will feature both plenary lectures by experts in the field and presentations of eight featured top abstracts selected for their relevance to the mechanism and biology of postoperative delirium in both pediatric and geriatric patients. The full text for each abstract can be found at the ASA abstract website.“Removing the Confusion about Delirium” by Jamie W. Sleigh, M.D.The University of Auckland, Hamilton, New Zealand.“Pediatric Delirium: Do We Know What We Think We Know” by Andrew Davidson, M.B.B.S., M.D.Royal Children’s Hospital, Melbourne, Australia.“Postoperative Changes in the Cerebrospinal Fluid Proteome Suggest a Role of the Complement Pathway in Postoperative Delirium” by Jake Thomas, B.S., Matt Foster, Ph.D., Joseph Lucas, Ph.D., Mary Wright, M.S., Joseph Mathew, M.D., M.B.A., Miles Berger, M.D., Ph.D., Michael Devinney, M.D., Ph.D.Duke University School of Medicine, Durham, North Carolina (J.T.); Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina (M.F., M.W., J.M., M.B., M.D.); Vital Statistics, L.L.C., Chapel Hill, North Carolina (J.L.)“Emergence Delirium and Behavior at 3 Months after General Anesthesia in Preschool Children” by Amira Joseph, M.D., David O. Warner, M.D., Yu Shi, M.D.Mayo Clinic College of Medicine, Rochester, Minnesota“Demographic Characteristics as Predictors of Clinical Outcomes in Very Elderly Adults” by Guillermo Madrid, M.D., M.Sc., Laura Cristina Moyano, M.D., Jairo Ricardo Moyano, M.D., Ph.D., Maria Jose Pelaez Jaramillo, M.D.Anesthesiology, Fundacion Santa Fe de Bogota, Bogota, Colombia“A Proteomic-derived Predictive Model for Postoperative Delirium in Cardiac Surgical Patients” by Tanvi Khera, M.D., Maria Carolina-Bittercourt Gonçalves, Ph.D., Shilpa Narayanan, B.A., Simon T. Dillon, Ph.D., Yoojin Jung, Ph.D., Hasan H. Otu, Ph.D., Long H. Ngo, Ph.D., Edward R. Marcantonio, M.D., Towia A. Libermann, Ph.D., Balachundhar Subramaniam, M.D.Anesthesia Critical Care and Pain Medicine, and Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts (T.K., M.C-B.G., S.N., S.T.D., Y.J., L.H.N., E.R.M., T.A.L., B.S.); Electrical and Computer Engineering, University of Nebraska–Lincoln, Lincoln, Nebraska (H.H.O.)“Anesthesia/Surgery Induces Delirium-like Behavior in Aged Mice Via Cells–Mediated Increase of TAU-PT217 in Blood” by Jing Lu, M.D., Ph.D., Feng Liang, Ph.D., Ping Bai, Ph.D., Zhengwang Sun, Ph.D., Wenjie Tian, M.D., Ph.D., Changning Wang, Ph.D., Edward R. Marcantonio, M.D., M.S., Guang Yang, Ph.D., Zhongcong Xie, M.D., Ph.D.Anesthesiology, Critical Care and Pain Medicine, Cardiology, and Radiology, Massachusetts General Hospital, Boston, Massachusetts (J.L., F.L., Z.S., W.T., C.W.); Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts (E.R.M.); Columbia University, New York, New York (G.Y.); Massachusetts General Hospital–Harvard Medical School, Boston, Massachusetts (P.B., Z.X.)“Postoperative Delirium and Altered Connectivity within the Default Mode Network and Hippocampus” by Heather Acuff, M.D., Ph.D., Laurel Zelnik, B.S., Joshua Siegel, M.D., Ph.D., Jacob Bolzenius, Ph.D., Mehdi Kafashan, Ph.D., Thomas Nguyen, B.S., Anhthi Luong, B.S., Michael S. Avidan, M.B., B.Ch., Tammie Benzinger, M.D., Ph.D., Ben Julian Palanca, M.D., Ph.D.Anesthesiology, and Washington University School of Medicine, Washington University in St. Louis, St. Louis, Missouri (H.A., L.Z., J.B., M.K., T.N., A.L., M.S.A., T.B., B.J.P.); PeaceHealth Medical Group Anesthesiology, Longview, Washington (J.S.)“Association of Malnutrition and Frailty with Postoperative Delirium in Older Patients after Hip Fracture Surgery” by Benayas Dereje Begashaw, B.Sc., Esteban Franco-Garcia, M.D., Marilyn Heng, M.D., M.P.H., Oluwaseun Johnson-Akeju, M.D., M.Sc., John A. Reich, M.D., Sadeq A. Quraishi, M.D.Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts (B.D.B., J.A.R., S.A.Q.); Department of Medicine, Department of Orthopaedic Surgery, and Department of Anesthesiology, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (E.F-G., M.H., O.J-A.)“Postoperative Delirium and Blood Brain Barrier Breakdown in Older Noncardiac Surgical Patients” by Megan Wong, B.S., Mary Cooter Wright, M.S., Pallavi Avasarala, Ayesha Syed, B.A., Edward R. Marcantonio, M.D., Niccolo Terrando, Ph.D., Joseph P. Mathew, M.D., M.B.A., Miles Berger, M.D., Ph.D., Michael Devinney, M.D.Duke University School of Medicine, Durham, North Carolina (M.W.); Duke University Medical Center, Durham, North Carolina (M.C.W., P.A., A.S., N.T., J.P.M., M.B., M.D.); Beth Israel Deaconess Medical Center, Boston, Massachusetts (E.R.M.)Anesthesiology is sponsoring two Best Abstract sessions: one in basic science and another in clinical science. The abstracts were chosen by a panel of editors who examined the highest scoring abstracts from the ASA subcommittees, choosing those with important scientific and clinical application and novelty. The following are summaries of the excellent abstracts that will be presented.Sunday, October 23, 2022, 1:00pmto 2:55pmRoom 243Michael J. Avram, Ph.D., Assistant Editor-in-Chief, Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Deborah J. Culley, M.D., Executive Editor, Anesthesiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; Martin J. London, M.D., Editor, Anesthesiology, University of California, San Francisco School of Medicine and the Veterans Affairs Medical Center, San Francisco, California.“Discovery of a Quinone Analog as a Novel Anesthetic Agent” by Richard Levy, M.D., Abhishek Srivastava, B.S., Keren Griffiths, M.D., Ph.D., Yash Somnay, M.D., Ph.D.Columbia University, New York, New YorkPropofol interferes with electron transfer at the level of coenzyme Q and induces excessive proton leak within mitochondria. Synthetic coenzyme Q analogs have similar biologic activity in vitro. The hypothesis that quinone analogs would induce propofol-like sedation and hypnosis was tested in mice using the short-chain coenzyme Q analog ubiquinone-5. Ubiquinone-5 immediately induced loss of righting reflex with an ED50 of 81 mg/kg, and latency to return of righting reflex was correlated with dose. Ubiquinone-5 induced excessive proton leak in isolated forebrain mitochondria, inhibited electron transport chain enzyme complex activities, and compromised mitochondrial membrane potential.“A Genetically Engineered Mouse that Improves TRPV1-mediated Insulin Release and Glucose Handling Is Protected from Cardiac Injury” by Eric Gross, M.D., Ph.D., Yang Bian, Ph.D., Shufang He, Ph.D.Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, California (E.G., Y.B.); Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, California, and Second Hospital of Anhui Medical University, Hefei City, Anhui Province, China (S.H.)Transient receptor potential vanilloid 1 (TRPV1) regulates myocardial reperfusion injury, but the region of TRPV1 important for limiting organ injury is unclear. Because TRPV1 activation antagonizes insulin release from pancreatic β cells, mice with a missense mutation in TRPV1 (K710N) were studied to determine whether a specific amino acid within the C terminus of TRPV1 causes resistance to cardiac injury by modifying insulin release and glucose handling. A discrete amino acid of TPRV1, K710, was found to regulate the response to a glucose challenge and insulin release, changes in which led to improved glycolytic handling and protection of cardiomyocytes from cellular stress.“β-Arrestin Recruitment Does Not Explain Respiratory Depression from Opioids of the Nitazene Family” by Barbara Palkovic, M.D., Daniel J. Sprague, M.D., Ph.D., John D. McCorvy, Ph.D., Maggie M. Calkins, B.S., Thomas M. Langer III, M.D., Ph.D., Jennifer J. Callison, B.S., Eckehard A. Stuth, M.D., Astrid G. Stucke, M.D.Faculty of Medicine Osijek, Osijek, Croatia (B.P.); Cell Biology, Neurobiology and Anatomy, and Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin (D.J.S., J.D.M., M.M.C., T.M.L., J.J.C., E.A.S., A.G.S)Opioid-induced respiratory depression has been attributed to recruitment of the β-arrestin scaffold rather than G protein activation, both of which result from binding of the agonist to the mu-opioid receptor. The hypothesis that respiratory depression strongly correlates with β-arrestin recruitment was tested by studying in vitro and in vivo effects of opioids of the nitazene family that are biased toward either mechanism. Although activation of G protein versus β-arrestin pathway by nitazene mu-opioid receptor agonists varied with their molecular structure, the degree of β-arrestin recruitment did not correlate with the magnitude of respiratory depression.“Effects of Low versus High Positive End-expiratory Pressure on Mechanical Power and Pulmonary Neutrophilic Inflammation in Experimental Acute Respiratory Distress Syndrome” by Nikola Anusic, M.D., Martin Scharffenberg, M.D., Robert Huhle, M.D., Jakob Wittenstein, M.D., Marcelo Gama De Abreu, M.D.Outcomes Research, Cleveland Clinic, Cleveland, Ohio (N.A.); Universitätsklinikum Carl Gustav Carus Dresden, Dresden, Germany (M.S., R.H., J.W.); Outcomes Research Department, Anesthesiology Institute, Cleveland Clinic Foundation, Cleveland, Ohio (M.G.D.A.)Mechanical ventilation may cause ventilator-induced lung injury. Mechanical power, which describes the energy transferred to the respiratory system per unit time, has been associated with surrogates of ventilator-induced lung injury. The hypothesis that protective mechanical ventilation strategies using different levels of positive end-expiratory pressure differ in their mechanical power and pulmonary neutrophilic inflammation was tested in a randomized study of 24 anesthetized pigs in which lung injury had been induced by saline lavage. Protective mechanical ventilation with low compared to high positive end-expiratory pressure increased mechanical power and worsened lung inflammation.“Altered Astrocytic Bioenergetics and Delayed Emergence from Propofol in a Rodent Model of Alcohol Intolerance” by Candida Goodnough, M.D., Ph.D., Ryan Ozawa, B.S., Rafaela Rodrigues Hell, Ph.D., Katie Chang, Eric R. Gross, M.D., Ph.D.Stanford University, Stanford, CaliforniaAlcohol intolerance is due to a genetic variant in the mitochondrial enzyme aldehyde dehydrogenase 2 (ALDH2*2), which limits the metabolism of acetaldehyde, a metabolite of ethanol. The hypothesis that the inactivating genetic variant ALDH2*2 will delay recovery from anesthesia due to an altered mitochondrial redox state was tested in wild-type ALDH2 and ALDH2*2 knock-in mice. There was no difference between groups in time to loss of righting reflex or duration of propofol-induced general anesthesia, but ALDH2*2 mice had delayed recovery from anesthesia as defined by behavioral tests. Bioenergetics were altered in mitochondria of ALDH2*2 astrocytes at baseline and in the presence of propofol.“Mitigation of Burn-induced Motor Neuron Apoptosis, Synaptic Denervation, and Muscle Wasting by Decreasing Spinal Microglia Inflammatory Responses” by Jingyuan Chen, M.D., Ph.D., Yoshinori Kitagawa, M.D., Ph.D., Yang Ren, M.D., Shingo M.D., Ph.D., M.D., of Anesthesiology, The Hospital, University, China University Hospital, Hospital for and Harvard Medical School, Boston, Massachusetts hypothesis that release a in and after injury and that of activation by would these was tested in wild-type and mice or degree injury The agonist or saline was after injury. activation, as by release, and and in wild-type but not of the in Is in the Pain after Brain Injury” by Chen, M.D., Ph.D., David J. M.D., of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford, California School of Medicine, California hypothesis that injury in response to a injury by of was tested in a of injury. with injury a of after a injury. recovery from was on on the in the of these the of after Pain by Inflammation and in by M.D., Ph.D., M.D., M.D., M.D., M.D., Chen, of Anesthesiology, Hospital, Medical University of and were to the changes of of to and Pain were in the groups the and and 24 after were for 24 after the the mechanical and latency the and were and compared to the of of on Inflammation in by M.S., Wang, M.S., M.S., M.S., M.S., Department, Hospital of Medical University, effects of different of on inflammation were studied in a of or were for had effects on and and and but and and and but Anesthetic of the A for Clinical by M.D., M.D., Eric B.S., A. Davidson, Ph.D., Ph.D., R. M.D., Ph.D., D. M.D., Ph.D.Anesthesiology, School of Medicine and New of for is is a major are at high to have The of these in vitro was to in and as a as a and its release in response to compared to its release from and from The rapidly and at the highest the of and Anesthesia in with Brain Injury” by M.D., M.D., M.D., of Anesthesiology, University of College of Medicine, effects of general injury, and to on and in and their was tested in Surgery, injury, and to in led to and in the and in their in by M.D., M.Sc., M.D., and Pain Medicine, Hospital, University College of Medicine, for University, has been to the from important in induced by The of with the effects of in was studied in mice were induced by for 1 The was of was and of was in mice with in an and had a October 23, 2022, 243Michael J. Avram, Ph.D., Assistant Editor-in-Chief, Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Deborah J. Culley, M.D., Executive Editor, Anesthesiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; Martin J. London, M.D., Editor, Anesthesiology, University of California, San Francisco School of Medicine and the Veterans Affairs Medical Center, San Francisco, of to Clinical by M.D., Ph.D., M.D.Anesthesiology, and Department of Electrical and Computer Engineering, University of California in a is important for clinical and of surgical by the were from the were from and with was to these patients. with and were the Patients with 3 of the of unit and of for Pain by M.D., Brian M. M.D., John J. M.D., W. M.D., M.D., A. M.D., M.D., M.D., M.D., M. of Anesthesiology, and Department of Surgery, University of California San San California Pain and study for the of after postoperative who had had a on a to of to versus to in patients the 3 by had after 1 in one and of the by Michael M.D., Katie J. M.D., M.P.H., M.D., Michael R. Anesthesiology Perioperative Medicine, University, University of Washington University of Michigan, Ann Arbor, of surgical patients who had from previous was compared to that of a of surgical patients previous in a study of between and within of of the patients within of and of and by A. M.D., D. M.D., S. M.D.Anesthesiology, Duke University, Durham, North Carolina University, University Medical Center, California University of City, and and using an A randomized trial compared with anesthesia in patients. the and and the within a with than anesthesia by for for and for Brain Connectivity Changes in following by Ben Palanca, M.D., Ph.D., Thomas A. Ph.D., M. M.S., Thomas Nguyen, B.S., M.D., R. M.D., M.D., Anesthesiology, and Washington University School of Medicine in St. Louis, St. Louis, Missouri T.N., and Medicine, University of School of Medicine, University of Medicine, Chicago, The effects of on after were in a study of who sessions of a for 1 or an for 1 in a randomized in to primary at 2 and 24 after that are with changes in of the to Orthopaedic and versus A by M.D., Brian M.D., M.D., University School of Medicine, is about level of be as a for patients no in a determine a is and the of patients no being were to a of or a of in A of led to a an in of Pulmonary in by M.D., M.D., M.Sc., M.D., M.Sc., Michael M.Sc., Gustav M.D., M.D., of Anesthesiology, University of Germany of and University of Germany Department of University of Germany of Germany University of Germany and were in patients with patients with respiratory and and molecular by these were and increased with and were in than in and in were in than in and their and in and in Clinical by M.D., Ph.D., M.D., H. M.D., M.D., M.D., David R. M.D., J. M.D., M.D., General Hospital, Boston, Massachusetts Cleveland Clinic, Ohio and University, University of Pennsylvania of the University of Pennsylvania, Philadelphia, Pennsylvania School of Medicine, Stanford, California University of Medical School, Ann Arbor, Anesthesiology University of Washington University of the of a a defined as pressure than for at 1 a with the and did The patients a surgical for a duration of to Patients using for to the for to of and for Cardiac on and Pulmonary by M.D., M.D., M.D., M.S., M.D., A. M.D., M.S., M.D., of Outcomes Research, Department of Anesthesiology, and Department of Cleveland Clinic, Cleveland, Ohio hypothesis that of and using a of and would postoperative and respiratory the 3 postoperative was tested in a randomized trial of patients cardiac for or There was no difference in the and pulmonary the 3 postoperative between patients who and those who had and on in an Elderly by P. M.D., M.D., Ph.D., M.D., Michael Ph.D., Ph.D., B.Sc., M.D., of Anesthesiology, University Medical Center, Pennsylvania from opioids in that is biased toward activation of the pathway that is associated with with recruitment of the β-arrestin pathway that is associated with The hypothesis that would respiratory depression than at was tested in a randomized trial of and to 2 was of respiratory in to the respiratory of 2 within 3 of Vital after in the of by M.D., M.D., M.D., Ph.D., University, Stanford University, Stanford, study of patients primary with an was to determine whether a saline the can from the Patients were and an upon to the recovery either a saline or no Clinical of was after the saline Anesthesia in with in Emergence Delirium” by M.D., M.D., Ph.D., M.D., of for and Medical University, hypothesis that pediatric anesthesia delirium may be by an anesthesia designed to to was tested in randomized trial the of pediatric anesthesia delirium after anesthesia at and at 1 and than for surgical postoperative were There was no difference between the groups in the of patients with a pediatric anesthesia delirium of or to in the Recruitment is October 2022, D. Kharasch, M.D., Ph.D., Editor-in-Chief, Anesthesiology, Duke University Medical Center, Durham, North by Anesthesiology, for the of Research, the of the ASA in Research and the M.D., will be will lectures on their The for Anesthesia and Research in and the of the Research will be There will be a on for Anesthesia and Research October 2022, 1:15pmto 3:15pmRoom M.D., Ph.D., Editor, Anesthesiology, Columbia University Medical Center, New York, New of clinical trial by one of the and by a by another will on the and their on those and of their and in the This will be by a response from the of in A by G. of Anesthesiology and Critical Care Medicine, The Children’s Hospital of Philadelphia, Philadelphia, M.D., Department of Anesthesiology and Perioperative Medicine, University, Anesthesia with on with General Anesthesia with to Delirium: The by H. M.D., of Anesthesiology and Critical Care Medicine, University School of Medicine, G. M.D., Department of Anesthesiology Critical Care Medicine, University Medical Center, versus Noncardiac A by of Hospital Clinic of Research Institute, de W. M.D., University of City, in Patients Noncardiac Surgery” by M.D., of Research and and Department of Medicine, University, Hamilton, H. Levy, M.D., Executive Editor, Anesthesiology, Duke University, Durham, North

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