The Role of Machine Learning Models in Predicting Cirrhosis Mortality: A Systematic Review

Abstract

Liver cirrhosis affects millions of individuals worldwide and is one of the primary causes of mortality. Early mortality prediction for cirrhosis patients may increase the possibility for medical professionals to treat the illness successfully. This study assesses the ability of machine learning (ML) models to predict cirrhosis mortality. We followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to search for relevant literature across four different databases. We found 379 studies of which 10 were eligible for inclusion in the current study. We analyzed 10 retrospective studies that showed that ML models outperformed conventional scores in predicting the death rate from end-stage liver disease (ESLD). Interestingly, models that used more parameters, such as patient demographics and extensive laboratory testing, exhibited higher prediction accuracy. With an area under the receiver operating characteristic (AUROC) ranging from 0.71 to 0.96, ML models showed consistently significant gains over traditional prognostic ratings. This review emphasizes how ML models might improve ESLD patient death prediction. Because machine learning models are more accurate than conventional approaches, it is important to incorporate data-driven informatics technologies into clinical settings. Additional validation and openness are required to guarantee model dependability and interpretability before ML may be used in clinical practice. The goal of future research should be to create reliable, interpretable models that may be used successfully in a variety of clinical contexts, enhancing ESLD patient treatment and results.

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