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Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity
2025·28 Zitationen·JAMAOpen Access
Volltext beim Verlag öffnen28
Zitationen
344
Autoren
2025
Jahr
Abstract
In a large convenience sample, a positive tau PET scan occurred at a nonnegligible rate among cognitively unimpaired individuals, and the combination of Aβ PET positivity and tau PET positivity was associated with a high risk of clinical progression in both preclinical and symptomatic stages of AD. These findings underscore the potential of tau PET as a biomarker for staging AD pathology.
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Autoren
- Alexis Moscoso
- Fiona Heeman
- Sheelakumari Raghavan
- Alejandro Costoya‐Sánchez
- Martijn van Essen
- Ismini Mainta
- Valle Camacho
- Omar Darío Rodríguez-Fonseca
- Jesús Silva‐Rodríguez
- Andrés Perissinotti
- Yuna Gu
- Jihwan Yun
- Débora Elisa Peretti
- Federica Ribaldi
- Emma M. Coomans
- Wagner S. Brum
- Michel J. Grothe
- Pablo Aguiar
- Gérard N. Bischof
- Alexander Drzezga
- Sang Won Seo
- Sylvia Villeneuve
- Maura Malpetti
- John T. O’Brien
- James B. Rowe
- Elsmarieke van de Giessen
- Rik Ossenkoppele
- William Jagust
- Ruben Smith
- Oskar Hansson
- Giovanni B. Frisoni
- Valentina Garibotto
- David N. Soleimani‐Meigooni
- Marı́a C. Carrillo
- Bradford C. Dickerson
- Renaud La Joie
- Gil D. Rabinovici
- Liana G. Apostolova
- Pamela LaMontagne
- Michael J. Pontecorvo
- Keith A. Johnson
- Reisa A. Sperling
- Michael W. Weiner
- Ronald C. Petersen
- Clifford R. Jack
- Prashanthi Vemuri
- Michael Schöll
- Angela Tam
- Anne Labonté
- Alexa Pichet Binette
- Anne‐Marie Faubert
- Axel Mathieu
- Cécile Madjar
- Charles Edouard Carrier
- Christian Dansereau
- Christina Kazazian
- Claude Lepage
- Cynthia Picard
- David Maillet
- Diane Michaud
- Doris Couture
- Doris Dea
- A. Claudio Cuello
- Alan Barkun
- Alan C. Evans
- Blandine Courcot
- Christine Tardif
- Clément Debacker
- David Fontaine
- David S. Knopman
- Gerhard Multhaup
- Jamie Near
- Jeannie‐Marie Leoutsakos
- Jean‐Robert Maltais
- Jason Brandt
- Jens C. Pruessner
- John C. Morris
- John C.S. Breitner
- Judes Poirier
- Laksanun Cheewakriengkrai
- D. Louis Collins
- M. Mallar Chakravarty
- Mark A. Sager
- Marina Dauar‐Tedeschi
- Mark J. Eisenberg
- Natasha Rajah
- Paul Aisen
- Paule‐Joanne Toussaint
- Pedro Rosa‐Neto
- Bellec Pierre
- Penelope Kostopoulos
- Pierre Étienne
- Pierre N. Tariot
- Pierre Orban
- Rick Hoge
- Ronald J. Thomas
- Serge Gauthier
- Suzanne Craft
- Thomas J. Montine
- Vasavan Nair
- Véronique D. Bohbot
- Vinod Venugopalan
- Vladimir Fonov
- Yasser Ituria‐Medina
- Zaven S. Khachaturian
- Eduard Teigner
- Elena Anthal
- Elsa Yu
- Fabiola Ferdinand
- Galina Pogossova
- Ginette Mayrand
- Guerda Duclair
- Guylaine Gagné
- Holly Newbold‐Fox
- Illana Leppert
- Isabelle Vallée
- Jacob W. Vogel
- Jennifer Tremblay‐Mercier
- Joanne Frenette
- Josée Frappier
- Justin Kat
- Justin Miron
- Karen Wan
- Laura Mahar
- Leopoldina Carmo
- Louise Théroux
- Mahsa Dadar
- Marianne Dufour
- Marie‐Élyse Lafaille‐Magnan
- Melissa Appleby
- Mélissa Savard
- Miranda Tuwaig
- Mirela Petkova
- Pierre Rioux
- P.T. Meyer
- Rana El‐Khoury
- Renee Gordon
- Renuka Giles
- Samir Das
- Seqian Wang
- Shirin Tabrizi
- Sulantha Mathotaarachchi
- Sylvie Dubuc
- Tanya Lee
- Thomas Beaudry
- Valérie Gervais
- Véronique Pagé
- Julie Gonneaud
- Tharick A. Pascoal
- René Desautels
- Fatiha Benbouhoud
- Eunice Farah Saint‐Fort
- Sander C.J. Verfaillie
- Sarah Farzin
- Alyssa Salaciak
- Stéphanie Tullo
- Étienne Vachon‐Presseau
- Leslie‐Ann Daoust
- Theresa Köbe
- R. Nathan Spreng
- Melissa McSweeney
- Nathalie Nilsson
- Morteza Pishnamazi
- Christophe Bedetti
- Louise Hudon
- Claudia Greco
- Marianne Chapleau
- Frédéric St‐Onge
- Sophie Boutin
- Maiya R. Geddes
- Simon Ducharme
- Gabriel Jean
- Elisabeth Sylvain
- Marie‐Josee Élie
- Gloria Leblond‐Baccichet
- Jean‐Paul Soucy
- Hazal Ozlen
- Julie Bailly
- Béry Mohammediyan
- Yalin Chen
- Jordana Remz
- Dorene M. Rentz
- Rebecca E. Amariglio
- Deborah Blacker
- Rachel F. Buckley
- Jasmeer P. Chhatwal
- Brad C. Dickerson
- Nancy J. Donovan
- Michelle E. Farrell
- Geoffroy Gagliardi
- Jennifer R. Gatchel
- Edmarie Guzmán‐Vélez
- Heidi I.L. Jacobs
- Roos J. Jutten
- Cristina Lois Gómez
- Gad A. Marshall
- Kate Oaoo
- Enmanuelle Pardilla‐Delgado
- Julie Price
- Prokopis C. Prokopiou
- Yakeel T. Quiroz
- Gretchen Reynolds
- Aaron P. Schultz
- Stephanie A. Schultz
- Jorge Sepulcre
- Irina A. Skylar-Scott
- Patrizia Vannini
- Clara Vila‐Castelar
- Hyun‐Sik Yang
- John Q. Trojanowki
- Arthur W. Toga
- Laurel Beckett
- Robert C Green
- Andrew J. Saykin
- John C. Morris
- Richard J. Perrin
- Leslie M. Shaw
- William Z. Potter
- Lisa L. Barnes
- Marie Bernard
- Héctor Alfredo Baptista González
- Carole Ho
- John Hsiao
- Jonathan Jackson
- Eliezer Masliah
- Donna Masterman
- Nicolai Franzmeier
- Laurie Ryan
- Nina Silverberg
- Adam Fleisher
- Juliet Fockler
- Cat Conti
- Dallas P. Veitch
- John Neuhaus
- Chengshi Jin
- Rachel L. Nosheny
- Mariam Ashford
- Derek Flenniken
- Adrienne Kormos
- Tom Montine
- Michael Rafii
- Rema Raman
- Gustavo Jimenez‐Maggiora
- Michael Donohue
- Devon Gessert
- Jennifer Salazar
- Caileigh Zimmerman
- Yuliana Cabrera
- Sarah Walter
- Garrett Miller
- Godfrey Coker
- Taylor Clanton
- Lindsey Hergesheimer
- Stephanie Smith
- Olusegun Adegoke
- Payam Mahboubi
- Shelley Moore
- Jeremy Pizzola
- Elizabeth Shaffer
- Danielle Harvey
- Arvin Forghanian-Arani
- Bret Borowski
- Chad Ward
- Christopher G. Schwarz
- David T. Jones
- Jeff Gunter
- Kejal Kantarci
- Matthew L. Senjem
- Robert I. Reid
- Nick C. Fox
- Ian B. Malone
- Paul Thompson
- Sophia I. Thomopoulos
- Talia M. Nir
- Neda Jahanshad
- Charles DeCarli
- Alexander Knaack
- Evan Fletcher
- Duygu Tosun
- Stephanie R Chen
- Mark Choe
- Karen Crawford
- Paul A Yuschkevich
- Sandhitsu R. Das
- Robert A. Koeppe
- Eric M. Reiman
- Kewei Chen
- Chester A. Mathis
- Susan Landau
- Nigel J. Cairns
- Erin Householder
- Erin Franklin
- Haley Bernhardt
- Lisa Taylor‐Reinwald
- Magdalena Korecka
- Michal Figurski
- Scott Neu
- Kwangsik Nho
- Shannon L. Risacher
- Li Shen
- Tatiana M. Foroud
- Kelly Nudelman
- Kelley Faber
- Kristi Wilmes
- Leon J. Thal
- Jeffrey L. Dage
- Ani Eloyan
- Tatiana M. Foroud
- Bernardino Ghetti
- Lea T. Grinberg
- Dustin B. Hammers
- Kala Kirby
- Joel Kramer
- Robert A. Koeppe
- Walter A. Kukull
- Julien Legarde
- Melissa E. Murray
- Kathy L. Newell
- Angelina J. Polsinelli
- Alexander Taurone
- Maryanne Thangarajah
- Arthur W. Toga
- Alexandra Touroutoglou
- Alireza Atri
- David Clark
- Gregory S Day
- Ranjan Duara
- Neill R Graff-Radford
- Ian Grant
- Lawrence S. Honig
- Erik C. B. Johnson
- David T. Jones
- Joseph C. Masdeu
- Mario F. Mendez
- Erik S. Musiek
- Chiadi U. Onyike
- Meghan Riddle
- Emily Rogalskı
- Steven Salloway
- Sharon J. Sha
- Raymond Scott Turner
- Thomas S. Wingo
- S. J. Wolk
- Kyle Womack
Institutionen
- Instituto de Investigación Sanitaria de Santiago(ES)
- University of Gothenburg(SE)
- Mayo Clinic(US)
- Instituto de Salud Carlos III(ES)
- Centro de Investigación Biomédica en Red(ES)
- Universidade de Santiago de Compostela(ES)
- Sahlgrenska University Hospital(SE)
- University Hospital of Geneva(CH)
- Universitat Autònoma de Barcelona(ES)
- Hospital de Sant Pau(ES)
- Hospital Universitario Lucus Augusti(ES)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine(ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer(ES)
- Samsung Medical Center(KR)
- Sungkyunkwan University(KR)
- University of Geneva(CH)
- Amsterdam Neuroscience(NL)
- Vrije Universiteit Amsterdam(NL)
- Universidade Federal do Rio Grande do Sul(BR)
- Center for Research in Molecular Medicine and Chronic Diseases(ES)
- Forschungszentrum Jülich(DE)
- University Hospital Cologne(DE)
- German Center for Neurodegenerative Diseases(DE)
- Samsung (South Korea)(KR)
- Douglas Mental Health University Institute(CA)
- McGill Genome Centre(CA)
- McGill University(CA)
- University of Cambridge(GB)
- UK Dementia Research Institute(GB)
- Cambridge University Hospitals NHS Foundation Trust(GB)
- MRC Cognition and Brain Sciences Unit(GB)
- Medical Research Council(GB)
- Lund University(SE)
- University of California, Berkeley(US)
- Skåne University Hospital(SE)
- Centre d'Imagerie BioMedicale(CH)
- University of California, San Francisco(US)
- Lawrence Berkeley National Laboratory(US)
- Alzheimer's Association(US)
- Massachusetts General Hospital(US)
- Harvard University(US)
- Alzheimer’s Disease Neuroimaging Initiative(US)
- Indiana University – Purdue University Indianapolis(US)
- Indiana University School of Medicine
- Washington University in St. Louis(US)
- Eli Lilly (United States)(US)
- Gordon Center for Medical Imaging(US)
- Brigham and Women's Hospital(US)
- San Francisco VA Medical Center(US)
- National Hospital for Neurology and Neurosurgery(GB)
- University College London(GB)
Themen
Medical Imaging Techniques and ApplicationsAdvanced MRI Techniques and ApplicationsAdvanced Neuroimaging Techniques and Applications