The evaluation illusion of large language models in medicine

Abstract

While large language models (LLMs) hold promise for transforming clinical healthcare, current comparisons and benchmark evaluations of large language models in medicine often fail to capture real-world efficacy. Specifically, we highlight how key discrepancies arising from choices of data, tasks, and metrics can limit meaningful assessment of translational impact and cause misleading conclusions. Therefore, we advocate for rigorous, context-aware evaluations and experimental transparency across both research and deployment.

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