Hippocampus Radiomic Biomarkers for the Diagnosis of Amnestic Mild Cognitive Impairment: A Machine Learning Method

Abstract

<strong>Background</strong>: Recent evidence suggests the presence of hippocampal neuroanatomical abnormalities in subjects of amnestic mild cognitive impairment (aMCI). Our study aimed to identify the radiomic biomarkers of the hippocampus for building the classification models in aMCI diagnosis. <strong>Methods</strong>: For this target, we recruited 42 subjects with aMCI and 44 normal controls (NC). The right and left hippocampi were segmented for each subject using an efficient learning-based method. Then, the radiomic analysis was applied to calculate and select the radiomic features. Finally, two logistic regression models were built based on the selected features obtained from the right and left hippocampi. <strong>Results</strong>: There were 385 features derived after calculation, and four features remained after feature selection from each group of data. The area under the receiver operating characteristic (ROC) curve, specificity, sensitivity, positive predictive value, negative predictive value, precision, recall, and <em>F</em>-score of the classification evaluation index of the right hippocampus logistic regression model were 0.76, 0.71, 0.69, 0.69, 0.71, 0.69, 0.69, and 0.69, and those of the left hippocampus model were 0.79, 0.71, 0.54, 0.64, 0.63, 0.64, 0.54, and 0.58, respectively. <strong>Conclusion</strong>: Results demonstrate the potential hippocampal radiomic biomarkers are valid for the aMCI diagnosis. The MRI-based radiomic analysis, with further improvement and validation, can be used to identify patients with aMCI and guide the individual treatment.

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