Graph-Convolutional-Beta-VAE for synthetic abdominal aortic aneurysm generation

Abstract

Abstract Synthetic data generation plays a crucial role in medical research by mitigating privacy concerns and enabling large-scale patient data analysis. This study presents a Graph Convolutional Neural Network combined with a Beta-Variational Autoencoder (GCN- $$\beta$$ -VAE) framework for generating synthetic Abdominal Aortic Aneurysms (AAA). Using a small real-world dataset, our approach extracts key anatomical features and captures complex statistical relationships within a compact disentangled latent space. To address data limitations, low-impact data augmentation based on Procrustes analysis was employed, preserving anatomical integrity. The generation strategies, both deterministic and stochastic, manage to enhance data diversity while ensuring realism. Compared to PCA-based approaches, our model performs more robustly on unseen data by capturing complex, nonlinear anatomical variations. This enables more comprehensive clinical and statistical analyses than the original dataset alone. The resulting synthetic AAA dataset preserves patient privacy while providing a scalable foundation for medical research, device testing, and computational modeling. Graphical abstract

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